About POU domain, class 6, transcription factor 2
POU domain, class 6, transcription factor 2 (POU6F2) is a protein
from Homo sapiens identified by UniProt accession
P78424, 691 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | POU domain, class 6, transcription factor 2 |
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| UniProt accession | P78424 |
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| Gene | POU6F2 |
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| Organism | Homo sapiens |
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| Length | 691 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.46
- body fat percentage · score 0.44
- Nephroblastoma · score 0.42
- mathematical ability · score 0.42
- intraocular pressure measurement · score 0.41
- grip strength measurement · score 0.41
- body mass index · score 0.40
- vital capacity · score 0.37
- fat body mass · score 0.34
- lean body mass · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78424-F1 | alphafold | PREDICTED | 47.27 | — |
Amino-acid sequence (691 residues)
MSALLQDPMI AGQVSKPLLS VRSEMNAELR GEDKAATSDS ELNEPLLAPV ESNDSEDTPS KLFGARGNPA LSDPGTPDQH QASQTHPPFP VGPQPLLTAQ QLASAVAGVM PGGPPALNQP ILIPFNMAGQ LGGQQGLVLT LPTANLTNIQ GLVAAAAAGG IMTLPLQNLQ ATSSLNSQLQ QLQLQLQQQQ QQQQQQPPPS TNQHPQPAPQ APSQSQQQPL QPTPPQQPPP ASQQPPAPTS QLQQAPQPQQ HQPHSHSQNQ NQPSPTQQSS SPPQKPSQSP GHGLPSPLTP PNPLQLVNNP LASQAAAAAA AMSSIASSQA FGNALSSLQG VTGQLVTNAQ GQIIGTIPLM PNPGPSSQAA SGTQGLQVQP ITPQLLTNAQ GQIIATVIGN QILPVINTQG ITLSPIKPGQ QLHQPSQTSV GQAASQGNLL HLAHSQASMS QSPVRQASSS SSSSSSSSAL SVGQLVSNPQ TAAGEVDGVN LEEIREFAKA FKIRRLSLGL TQTQVGQALS ATEGPAYSQS AICRHTILRS HFFLPQEAQE NTIASSLTAK LNPGLLYPAR FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI GSEPSKKRKR RTSFTPQALE ILNAHFEKNT HPSGQEMTEI AEKLNYDREV VRVWFCNKRQ ALKNTIKRLK QHEPATAVPL EPLTDSLEEN S
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