About Homeobox protein Nkx-6.1
Homeobox protein Nkx-6.1 (NKX6-1) is a protein
from Homo sapiens identified by UniProt accession
P78426, 367 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Homeobox protein Nkx-6.1 |
|---|
| UniProt accession | P78426 |
|---|
| Gene | NKX6-1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 367 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.43
- peak expiratory flow · score 0.29
- adolescent idiopathic scoliosis · score 0.27
- daytime rest measurement · score 0.27
- neurodegenerative disease · score 0.13
- cutaneous melanoma · score 0.11
- amyotrophic lateral sclerosis · score 0.05
- Drugs used in diabetes use measurement · score 0.05
- chronic pancreatitis · score 0.05
- hyperinsulinemic hypoglycemia, familial, 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78426-F1 | alphafold | PREDICTED | 60.02 | — |
Amino-acid sequence (367 residues)
MLAVGAMEGT RQSAFLLSSP PLAALHSMAE MKTPLYPAAY PPLPAGPPSS SSSSSSSSSP SPPLGTHNPG GLKPPATGGL SSLGSPPQQL SAATPHGIND ILSRPSMPVA SGAALPSASP SGSSSSSSSS ASASSASAAA AAAAAAAAAA SSPAGLLAGL PRFSSLSPPP PPPGLYFSPS AAAVAAVGRY PKPLAELPGR TPIFWPGVMQ SPPWRDARLA CTPHQGSILL DKDGKRKHTR PTFSGQQIFA LEKTFEQTKY LAGPERARLA YSLGMTESQV KVWFQNRRTK WRKKHAAEMA TAKKKQDSET ERLKGASENE EEDDDYNKPL DPNSDDEKIT QLLKKHKSSS GGGGGLLLHA SEPESSS
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