About ATP-sensitive inward rectifier potassium channel 10
ATP-sensitive inward rectifier potassium channel 10 (KCNJ10) is a protein
from Homo sapiens identified by UniProt accession
P78508, 379 residues long.
MolForge cross-references it against 0 known binders and
360 disease associations.
Target properties
| Protein name | ATP-sensitive inward rectifier potassium channel 10 |
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| UniProt accession | P78508 |
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| Gene | KCNJ10 |
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| Organism | Homo sapiens |
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| Length | 379 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (360)
Diseases linked to this target (Open Targets).
- EAST syndrome · score 0.82
- autosomal recessive nonsyndromic hearing loss 4 · score 0.64
- Pendred syndrome · score 0.59
- hearing loss, autosomal recessive · score 0.51
- hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency · score 0.44
- genetic disorder · score 0.38
- Sensorineural hearing impairment · score 0.33
- Microcephaly · score 0.33
- renal tubule disease · score 0.33
- cerebellar ataxia · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78508-F1 | alphafold | PREDICTED | 82.44 | — |
Amino-acid sequence (379 residues)
MTSVAKVYYS QTTQTESRPL MGPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELD PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES LREQAEKEGS ALSVRISNV
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