Biogenesis of lysosome-related organelles complex 1…

About Biogenesis of lysosome-related organelles complex 1 subunit 1

Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1) is a protein from Homo sapiens identified by UniProt accession P78537, 153 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Biogenesis of lysosome-related organelles complex 1 subunit 1
UniProt accession	P78537
Gene	BLOC1S1
Organism	Homo sapiens
Length	153 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

Severe global developmental delay · score 0.50
epilepsy · score 0.50
neurodegenerative disease · score 0.30
Myopia · score 0.16
refractive error · score 0.13
self reported educational attainment · score 0.11
Hypermetropia · score 0.11
refractive error measurement · score 0.11
hepatocellular carcinoma · score 0.09
age at onset · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78537-F1	alphafold	PREDICTED	89.03	—

Amino-acid sequence (153 residues)

MAPGSRGERS SFRSRRGPGV PSPQPDVTML SRLLKEHQAK QNERKELQEK RRREAITAAT CLTEALVDHL NVGVAQAYMN QRKLDHEVKT LQVQAAQFAK QTGQWIGMVE NFNQALKEIG DVENWARSIE LDMRTIATAL EYVYKGQLQS APS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1)