About Arginase-2, mitochondrial
Arginase-2, mitochondrial (ARG2) is a protein
from Homo sapiens identified by UniProt accession
P78540, 354 residues long.
MolForge cross-references it against 0 known binders and
220 disease associations.
Target properties
| Protein name | Arginase-2, mitochondrial |
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| UniProt accession | P78540 |
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| Gene | ARG2 |
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| Organism | Homo sapiens |
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| Length | 354 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (220)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.26
- creatinine measurement · score 0.16
- neoplasm · score 0.11
- cancer · score 0.10
- acute kidney failure · score 0.08
- melanoma · score 0.07
- glomerular filtration rate · score 0.06
- infection · score 0.06
- infect · score 0.06
- breast cancer · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78540-F1 | alphafold | PREDICTED | 92.77 | — |
Amino-acid sequence (354 residues)
MSLRGSLSRL LQTRVHSILK KSVHSVAVIG APFSQGQKRK GVEHGPAAIR EAGLMKRLSS LGCHLKDFGD LSFTPVPKDD LYNNLIVNPR SVGLANQELA EVVSRAVSDG YSCVTLGGDH SLAIGTISGH ARHCPDLCVV WVDAHADINT PLTTSSGNLH GQPVSFLLRE LQDKVPQLPG FSWIKPCISS ASIVYIGLRD VDPPEHFILK NYDIQYFSMR DIDRLGIQKV MERTFDLLIG KRQRPIHLSF DIDAFDPTLA PATGTPVVGG LTYREGMYIA EEIHNTGLLS ALDLVEVNPQ LATSEEEAKT TANLAVDVIA SSFGQTREGG HIVYDQLPTP SSPDESENQA RVRI
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