Endonuclease III-like protein 1 (NTHL1)

About Endonuclease III-like protein 1

Endonuclease III-like protein 1 (NTHL1) is a protein from Homo sapiens identified by UniProt accession P78549, 304 residues long. MolForge cross-references it against 0 known binders and 188 disease associations.

Target properties

Protein name	Endonuclease III-like protein 1
UniProt accession	P78549
Gene	NTHL1
Organism	Homo sapiens
Length	304 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (188)

Diseases linked to this target (Open Targets).

attenuated familial adenomatous polyposis · score 0.71
Familial adenomatous polyposis · score 0.70
cancer · score 0.57
hereditary neoplastic syndrome · score 0.57
Inherited cancer-predisposing syndrome · score 0.57
colorectal cancer · score 0.46
body mass index · score 0.23
skin basal cell carcinoma · score 0.19
esophageal adenocarcinoma · score 0.19
breast carcinoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78549-F1	alphafold	PREDICTED	82.58	—

Amino-acid sequence (304 residues)

MTALSARMLT RSRSLGPGAG PRGCREEPGP LRRREAAAEA RKSHSPVKRP RKAQRLRVAY EGSDSEKGEG AEPLKVPVWE PQDWQQQLVN IRAMRNKKDA PVDHLGTEHC YDSSAPPKVR RYQVLLSLML SSQTKDQVTA GAMQRLRARG LTVDSILQTD DATLGKLIYP VGFWRSKVKY IKQTSAILQQ HYGGDIPASV AELVALPGVG PKMAHLAMAV AWGTVSGIAV DTHVHRIANR LRWTKKATKS PEETRAALEE WLPRELWHEI NGLLVGFGQQ TCLPVHPRCH ACLNQALCPA AQGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards