About Death domain-containing protein CRADD
Death domain-containing protein CRADD (CRADD) is a protein
from Homo sapiens identified by UniProt accession
P78560, 199 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Death domain-containing protein CRADD |
|---|
| UniProt accession | P78560 |
|---|
| Gene | CRADD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 199 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.59
- Intellectual disability · score 0.46
- body height · score 0.41
- lean body mass · score 0.40
- BMI-adjusted waist-hip ratio · score 0.38
- heel bone mineral density · score 0.38
- vital capacity · score 0.38
- appendicular lean mass · score 0.37
- BMI-adjusted hip circumference · score 0.37
- osteoarthritis, knee · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78560-F1 | alphafold | PREDICTED | 79.45 | — |
Amino-acid sequence (199 residues)
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE
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