About Phosphate-regulating neutral endopeptidase PHEX
Phosphate-regulating neutral endopeptidase PHEX (PHEX) is a protein
from Homo sapiens identified by UniProt accession
P78562, 749 residues long.
MolForge cross-references it against 0 known binders and
651 disease associations.
Target properties
| Protein name | Phosphate-regulating neutral endopeptidase PHEX |
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| UniProt accession | P78562 |
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| Gene | PHEX |
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| Organism | Homo sapiens |
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| Length | 749 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (651)
Diseases linked to this target (Open Targets).
- X-linked hypophosphatemia · score 0.84
- X-linked dominant hypophosphatemic rickets · score 0.78
- hypophosphatemic rickets · score 0.55
- Hypophosphatemia · score 0.43
- Bowing of the legs · score 0.34
- Lower limb pain · score 0.34
- autosomal dominant hypophosphatemic rickets · score 0.28
- vitamin D-dependent rickets, type 2 · score 0.26
- genetic disorder · score 0.19
- phosphate measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78562-F1 | alphafold | PREDICTED | 94.34 | — |
Amino-acid sequence (749 residues)
MEAETGSSVE TGKKANRGTR IALVVFVGGT LVLGTILFLV SQGLLSLQAK QEYCLKPECI EAAAAILSKV NLSVDPCDNF FRFACDGWIS NNPIPEDMPS YGVYPWLRHN VDLKLKELLE KSISRRRDTE AIQKAKILYS SCMNEKAIEK ADAKPLLHIL RHSPFRWPVL ESNIGPEGVW SERKFSLLQT LATFRGQYSN SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDYLDNST EAKSYRDALY KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDISPSENVV VRVPQYFKDL FRILGSERKK TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL PQWDKCVNFI ESALPYVVGK MFVDVYFQED KKEMMEELVE GVRWAFIDML EKENEWMDAG TKRKAKEKAR AVLAKVGYPE FIMNDTHVNE DLKAIKFSEA DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF YSASTNQIRF PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD PWWSTESEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL REAFRAYRKW INDRRQGLEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA AREQVQIGAH SPPQFRVNGA ISNFEEFQKA FNCPPNSTMN RGMDSCRLW
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