About Double-stranded RNA-specific editase 1
Double-stranded RNA-specific editase 1 (ADARB1) is a protein
from Homo sapiens identified by UniProt accession
P78563, 741 residues long.
MolForge cross-references it against 0 known binders and
173 disease associations.
Target properties
| Protein name | Double-stranded RNA-specific editase 1 |
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| UniProt accession | P78563 |
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| Gene | ADARB1 |
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| Organism | Homo sapiens |
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| Length | 741 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (173)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with hypotonia, microcephaly, and seizures · score 0.68
- body mass index · score 0.45
- body fat percentage · score 0.41
- body weight · score 0.40
- lean body mass · score 0.39
- fat body mass · score 0.37
- self reported educational attainment · score 0.34
- sex hormone-binding globulin measurement · score 0.33
- high density lipoprotein cholesterol measurement · score 0.31
- PHF-tau measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78563-F1 | alphafold | PREDICTED | 76.50 | — |
Amino-acid sequence (741 residues)
MDIEDEENMS SSSTDVKENR NLDNVSPKDG STPGPGEGSQ LSNGGGGGPG RKRPLEEGSN GHSKYRLKKR RKTPGPVLPK NALMQLNEIK PGLQYTLLSQ TGPVHAPLFV MSVEVNGQVF EGSGPTKKKA KLHAAEKALR SFVQFPNASE AHLAMGRTLS VNTDFTSDQA DFPDTLFNGF ETPDKAEPPF YVGSNGDDSF SSSGDLSLSA SPVPASLAQP PLPVLPPFPP PSGKNPVMIL NELRPGLKYD FLSESGESHA KSFVMSVVVD GQFFEGSGRN KKLAKARAAQ SALAAIFNLH LDQTPSRQPI PSEGLQLHLP QVLADAVSRL VLGKFGDLTD NFSSPHARRK VLAGVVMTTG TDVKDAKVIS VSTGTKCING EYMSDRGLAL NDCHAEIISR RSLLRFLYTQ LELYLNNKDD QKRSIFQKSE RGGFRLKENV QFHLYISTSP CGDARIFSPH EPILEGSRSY TQAGVQWCNH GSLQPRPPGL LSDPSTSTFQ GAGTTEPADR HPNRKARGQL RTKIESGEGT IPVRSNASIQ TWDGVLQGER LLTMSCSDKI ARWNVVGIQG SLLSIFVEPI YFSSIILGSL YHGDHLSRAM YQRISNIEDL PPLYTLNKPL LSGISNAEAR QPGKAPNFSV NWTVGDSAIE VINATTGKDE LGRASRLCKH ALYCRWMRVH GKVPSHLLRS KITKPNVYHE SKLAAKEYQA AKARLFTAFI KAGLGAWVEK PTEQDQFSLT P
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