About HLA class II histocompatibility antigen, DR beta 3 chain
HLA class II histocompatibility antigen, DR beta 3 chain (HLA-DRB3) is a protein
from Homo sapiens identified by UniProt accession
P79483, 266 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | HLA class II histocompatibility antigen, DR beta 3 chain |
|---|
| UniProt accession | P79483 |
|---|
| Gene | HLA-DRB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 266 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (59)
Diseases linked to this target (Open Targets).
- lymphoma · score 0.10
- chronic lymphocytic leukemia · score 0.08
- follicular lymphoma · score 0.04
- Mantle cell lymphoma · score 0.04
- diffuse large B-cell lymphoma · score 0.04
- type 1 diabetes mellitus · score 0.02
- COVID-19 · score 0.01
- Graves disease · score 0.01
- neuromyelitis optica · score 0.01
- sarcoidosis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P79483-F1 | alphafold | PREDICTED | 88.40 | — |
Amino-acid sequence (266 residues)
MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT ERVRYLDRYF HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK RGRVDNYCRH NYGVGESFTV QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF RNQKGHSGLQ PTGFLS
Explore HLA class II histocompatibility antigen, DR beta 3 chain with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets