C-C motif chemokine 8 (CCL8)

About C-C motif chemokine 8

C-C motif chemokine 8 (CCL8) is a protein from Homo sapiens identified by UniProt accession P80075, 99 residues long. MolForge cross-references it against 0 known binders and 289 disease associations.

Target properties

Protein name	C-C motif chemokine 8
UniProt accession	P80075
Gene	CCL8
Organism	Homo sapiens
Length	99 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (289)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.42
C-C motif chemokine 8 measurement · score 0.33
monocyte chemotactic protein-2 measurement · score 0.30
C-C motif chemokine 7 measurement · score 0.29
protein measurement · score 0.28
neurodegenerative disease · score 0.15
monocyte percentage of leukocytes · score 0.11
neoplasm · score 0.11
immature platelet fraction · score 0.09
cancer · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P80075-F1	alphafold	PREDICTED	88.69	—

Amino-acid sequence (99 residues)

MKVSAALLCL LLMAATFSPQ GLAQPDSVSI PITCCFNVIN RKIPIQRLES YTRITNIQCP KEAVIFKTKR GKEVCADPKE RWVRDSMKHL DQIFQNLKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards