C-X-C motif chemokine 6 (CXCL6)

About C-X-C motif chemokine 6

C-X-C motif chemokine 6 (CXCL6) is a protein from Homo sapiens identified by UniProt accession P80162, 114 residues long. MolForge cross-references it against 0 known binders and 323 disease associations.

Target properties

Protein name	C-X-C motif chemokine 6
UniProt accession	P80162
Gene	CXCL6
Organism	Homo sapiens
Length	114 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (323)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.66
neutrophil percentage of leukocytes · score 0.60
leukocyte count · score 0.59
lymphocyte percentage of leukocytes · score 0.49
C-X-C motif chemokine 6 measurement · score 0.43
monocyte percentage of leukocytes · score 0.39
blood protein measurement · score 0.39
myeloid white cell count · score 0.37
neurodegenerative disease · score 0.33
CXCL6 measurement · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P80162-F1	alphafold	PREDICTED	81.01	—

Amino-acid sequence (114 residues)

MSLPSSRAAR VPGPSGSLCA LLALLLLLTP PGPLASAGPV SAVLTELRCT CLRVTLRVNP KTIGKLQVFP AGPQCSKVEV VASLKNGKQV CLDPEAPFLK KVIQKILDSG NKKN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards