Neutrophil gelatinase-associated lipocalin (LCN2)

About Neutrophil gelatinase-associated lipocalin

Neutrophil gelatinase-associated lipocalin (LCN2) is a protein from Homo sapiens identified by UniProt accession P80188, 198 residues long. MolForge cross-references it against 0 known binders and 1,276 disease associations.

Target properties

Protein name	Neutrophil gelatinase-associated lipocalin
UniProt accession	P80188
Gene	LCN2
Organism	Homo sapiens
Length	198 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1276)

Diseases linked to this target (Open Targets).

endometrial cancer · score 0.24
head and neck squamous cell carcinoma · score 0.23
lung adenocarcinoma · score 0.20
squamous cell lung carcinoma · score 0.14
acute kidney failure · score 0.12
neoplasm · score 0.12
psoriasis · score 0.12
chronic kidney disease · score 0.12
neutrophil count · score 0.12
Sepsis · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P80188-F1	alphafold	PREDICTED	91.28	—

Amino-acid sequence (198 residues)

MPLGLLWLGL ALLGALHAQA QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK WYVVGLAGNA ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI RTFVPGCQPG EFTLGNIKSY PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR EYFKITLYGR TKELTSELKE NFIRFSKSLG LPENHIVFPV PIDQCIDG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards