Nucleobindin-2 (NUCB2)

About Nucleobindin-2

Nucleobindin-2 (NUCB2) is a protein from Homo sapiens identified by UniProt accession P80303, 420 residues long. MolForge cross-references it against 0 known binders and 377 disease associations.

Target properties

Protein name	Nucleobindin-2
UniProt accession	P80303
Gene	NUCB2
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (377)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.37
eosinophil count · score 0.33
neutrophil count · score 0.33
mean platelet volume · score 0.33
BMI-adjusted waist circumference · score 0.31
systolic blood pressure · score 0.31
body height · score 0.30
BMI-adjusted waist-hip ratio · score 0.27
smoking status measurement · score 0.25
leukocyte count · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P80303-F1	alphafold	PREDICTED	83.85	—

Amino-acid sequence (420 residues)

MRWRTILLQY CFLLITCLLT ALEAVPIDID KTKVQNIHPV ESAKIEPPDT GLYYDEYLKQ VIDVLETDKH FREKLQKADI EEIKSGRLSK ELDLVSHHVR TKLDELKRQE VGRLRMLIKA KLDSLQDIGM DHQALLKQFD HLNHLNPDKF ESTDLDMLIK AATSDLEHYD KTRHEEFKKY EMMKEHERRE YLKTLNEEKR KEEESKFEEM KKKHENHPKV NHPGSKDQLK EVWEETDGLD PNDFDPKTFF KLHDVNSDGF LDEQELEALF TKELEKVYDP KNEEDDMVEM EEERLRMREH VMNEVDTNKD RLVTLEEFLK ATEKKEFLEP DSWETLDQQQ FFTEEELKEY ENIIALQENE LKKKADELQK QKEELQRQHD QLEAQKLEYH QVIQQMEQKK LQQGIPPSGP AGELKFEPHI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards