Protein delta homolog 1 (DLK1)

About Protein delta homolog 1

Protein delta homolog 1 (DLK1) is a protein from Homo sapiens identified by UniProt accession P80370, 383 residues long. MolForge cross-references it against 0 known binders and 510 disease associations.

Target properties

Protein name	Protein delta homolog 1
UniProt accession	P80370
Gene	DLK1
Organism	Homo sapiens
Length	383 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (6)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (510)

Diseases linked to this target (Open Targets).

body height · score 0.52
platelet count · score 0.48
mean corpuscular volume · score 0.46
lean body mass · score 0.46
platelet crit · score 0.45
blood protein measurement · score 0.45
neutrophil count · score 0.44
mean platelet volume · score 0.44
mean corpuscular hemoglobin · score 0.43
leukocyte count · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P80370-F1	alphafold	PREDICTED	71.15	—

Amino-acid sequence (383 residues)

MTATEALLRV LLLLLAFGHS TYGAECFPAC NPQNGFCEDD NVCRCQPGWQ GPLCDQCVTS PGCLHGLCGE PGQCICTDGW DGELCDRDVR ACSSAPCANN RTCVSLDDGL YECSCAPGYS GKDCQKKDGP CVINGSPCQH GGTCVDDEGR ASHASCLCPP GFSGNFCEIV ANSCTPNPCE NDGVCTDIGG DFRCRCPAGF IDKTCSRPVT NCASSPCQNG GTCLQHTQVS YECLCKPEFT GLTCVKKRAL SPQQVTRLPS GYGLAYRLTP GVHELPVQQP EHRILKVSMK ELNKKTPLLT EGQAICFTIL GVLTSLVVLG TVGIVFLNKC ETWVSNLRYN HMLRKKKNLL LQYNSGEDLA VNIIFPEKID MTTFSKEAGD EEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards