About 4-aminobutyrate aminotransferase, mitochondrial
4-aminobutyrate aminotransferase, mitochondrial (ABAT) is a protein
from Homo sapiens identified by UniProt accession
P80404, 500 residues long.
MolForge cross-references it against 0 known binders and
191 disease associations.
Target properties
| Protein name | 4-aminobutyrate aminotransferase, mitochondrial |
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| UniProt accession | P80404 |
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| Gene | ABAT |
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| Organism | Homo sapiens |
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| Length | 500 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (191)
Diseases linked to this target (Open Targets).
- Gamma-aminobutyric acid transaminase deficiency · score 0.76
- GABA aminotransaminase deficiency · score 0.62
- mitochondrial DNA depletion syndrome · score 0.54
- West syndrome · score 0.51
- Focal impaired awareness seizure · score 0.47
- epilepsy · score 0.46
- complex partial epilepsy · score 0.46
- Global developmental delay · score 0.37
- partial epilepsy · score 0.37
- developmental and epileptic encephalopathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P80404-F1 | alphafold | PREDICTED | 93.76 | — |
Amino-acid sequence (500 residues)
MASMLLAQRL ACSFQHSYRL LVPGSRHISQ AAAKVDVEFD YDGPLMKTEV PGPRSQELMK QLNIIQNAEA VHFFCNYEES RGNYLVDVDG NRMLDLYSQI SSVPIGYSHP ALLKLIQQPQ NASMFVNRPA LGILPPENFV EKLRQSLLSV APKGMSQLIT MACGSCSNEN ALKTIFMWYR SKERGQRGFS QEELETCMIN QAPGCPDYSI LSFMGAFHGR TMGCLATTHS KAIHKIDIPS FDWPIAPFPR LKYPLEEFVK ENQQEEARCL EEVEDLIVKY RKKKKTVAGI IVEPIQSEGG DNHASDDFFR KLRDIARKHG CAFLVDEVQT GGGCTGKFWA HEHWGLDDPA DVMTFSKKMM TGGFFHKEEF RPNAPYRIFN TWLGDPSKNL LLAEVINIIK REDLLNNAAH AGKALLTGLL DLQARYPQFI SRVRGRGTFC SFDTPDDSIR NKLILIARNK GVVLGGCGDK SIRFRPTLVF RDHHAHLFLN IFSDILADFK
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