Immunoglobulin lambda variable 3-21 (IGLV3-21)

About Immunoglobulin lambda variable 3-21

Immunoglobulin lambda variable 3-21 (IGLV3-21) is a protein from Homo sapiens identified by UniProt accession P80748, 117 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Immunoglobulin lambda variable 3-21
UniProt accession	P80748
Gene	IGLV3-21
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.06
squamous cell carcinoma · score 0.05
sebaceous of Jadassohn nevus · score 0.05
esophageal adenocarcinoma · score 0.05
ulcerative colitis · score 0.03
cutaneous lupus erythematosus · score 0.02
central nervous system cancer · score 0.02
Crohn's disease · score 0.01
idiopathic pulmonary fibrosis · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P80748-F1	alphafold	PREDICTED	89.82	—

Amino-acid sequence (117 residues)

MAWTVLLLGL LSHCTGSVTS YVLTQPPSVS VAPGQTARIT CGGNNIGSKS VHWYQQKPGQ APVLVVYDDS DRPSGIPERF SGSNSGNTAT LTISRVEAGD EADYYCQVWD SSSDHPT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards