About G-protein-signaling modulator 2
G-protein-signaling modulator 2 (GPSM2) is a protein
from Homo sapiens identified by UniProt accession
P81274, 684 residues long.
MolForge cross-references it against 0 known binders and
187 disease associations.
Target properties
| Protein name | G-protein-signaling modulator 2 |
|---|
| UniProt accession | P81274 |
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| Gene | GPSM2 |
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| Organism | Homo sapiens |
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| Length | 684 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (187)
Diseases linked to this target (Open Targets).
- Chudley-McCullough syndrome · score 0.79
- hearing loss, autosomal recessive · score 0.55
- Rare genetic deafness · score 0.49
- deafness · score 0.49
- genetic disorder · score 0.41
- neurodegenerative disease · score 0.37
- Hearing impairment · score 0.12
- neoplasm · score 0.08
- cyst · score 0.08
- non-small cell lung carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P81274-F1 | alphafold | PREDICTED | 66.94 | — |
Amino-acid sequence (684 residues)
MEENLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA VQVGTEDLKT LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG EAKASGNLGN TLKVLGNFDE AIVCCQRHLD ISRELNDKVG EARALYNLGN VYHAKGKSFG CPGPQDVGEF PEEVRDALQA AVDFYEENLS LVTALGDRAA QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA ERRAYSNLGN AYIFLGEFET ASEYYKKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK AIDYHLKHLA IAQELNDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE ISREVGDKSG ELTARLNLSD LQMVLGLSYS TNNSIMSENT EIDSSLNGVR PKLGRRHSME NMELMKLTPE KVQNWNSEIL AKQKPLIAKP SAKLLFVNRL KGKKYKTNSS TKVLQDASNS IDHRIPNSQR KISADTIGDE GFFDLLSRFQ SNRMDDQRCC LQEKNCHTAS TTTSSTPPKM MLKTSSVPVV SPNTDEFLDL LASSQSRRLD DQRASFSNLP GLRLTQNSQS VLSHLMTNDN KEADEDFFDI LVKCQGSRLD DQRCAPPPAT TKGPTVPDED FFSLILRSQG KRMDEQRVLL QRDQNRDTDF GLKDFLQNNA LLEFKNSGKK SADH
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