About Prolactin-releasing peptide
Prolactin-releasing peptide (PRLH) is a protein
from Homo sapiens identified by UniProt accession
P81277, 87 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Prolactin-releasing peptide |
|---|
| UniProt accession | P81277 |
|---|
| Gene | PRLH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 87 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.10
- obesity due to melanocortin 4 receptor deficiency · score 0.08
- obesity due to pro-opiomelanocortin deficiency · score 0.06
- obesity due to leptin receptor gene deficiency · score 0.06
- obesity due to prohormone convertase I deficiency · score 0.06
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.06
- MODY · score 0.05
- obesity due to congenital leptin deficiency · score 0.05
- obesity due to SIM1 deficiency · score 0.05
- severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P81277-F1 | alphafold | PREDICTED | 65.85 | — |
Amino-acid sequence (87 residues)
MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV GRFGRRRATL GDVPKPGLRP RLTCFPLEGG AMSSQDG
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