Small ribosomal subunit protein mS22 (MRPS22)

About Small ribosomal subunit protein mS22

Small ribosomal subunit protein mS22 (MRPS22) is a protein from Homo sapiens identified by UniProt accession P82650, 360 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Small ribosomal subunit protein mS22
UniProt accession	P82650
Gene	MRPS22
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

hypotonia with lactic acidemia and hyperammonemia · score 0.77
46,XX gonadal dysgenesis · score 0.61
neurodegenerative disease · score 0.52
genetic disorder · score 0.47
mitochondrial disease · score 0.37
46 XX gonadal dysgenesis · score 0.34
Keloid · score 0.24
3-hydroxypropylmercapturic acid measurement · score 0.21
hair shape measurement · score 0.20
IGF-1 measurement · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P82650-F1	alphafold	PREDICTED	81.86	—

Amino-acid sequence (360 residues)

MAPLGTTVLL WSLLRSSPGV ERVCFRARIQ PWHGGLLQPL PCSFEMGLPR RRFSSEAAES GSPETKKPTF MDEEVQSILT KMTGLNLQKT FKPAIQELKP PTYKLMTQAQ LEEATRQAVE AAKVRLKMPP VLEERVPIND VLAEDKILEG TETTKYVFTD ISYSIPHRER FIVVREPSGT LRKASWEERD RMIQVYFPKE GRKILTPIIF KEENLRTMYS QDRHVDVLNL CFAQFEPDST EYIKVHHKTY EDIDKRGKYD LLRSTRYFGG MVWYFVNNKK IDGLLIDQIQ RDLIDDATNL VQLYHVLHPD GQSAQGAKDQ AAEGINLIKV FAKTEAQKGA YIELTLQTYQ EALSRHSAAS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards