Alpha-ketoglutarate dehydrogenase component 4 (KGD4)

About Alpha-ketoglutarate dehydrogenase component 4

Alpha-ketoglutarate dehydrogenase component 4 (KGD4) is a protein from Homo sapiens identified by UniProt accession P82909, 103 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Alpha-ketoglutarate dehydrogenase component 4
UniProt accession	P82909
Gene	KGD4
Organism	Homo sapiens
Length	103 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

reticulocyte measurement · score 0.11
leukocyte count · score 0.11
microphthalmia · score 0.09
nanophthalmia · score 0.07
nanophthalmos 2 · score 0.07
creatinine measurement · score 0.07
vital capacity · score 0.07
hypertension · score 0.07
eosinophil percentage of leukocytes · score 0.06
neutrophil count · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P82909-F1	alphafold	PREDICTED	73.73	—

Amino-acid sequence (103 residues)

MMGSKMASAS RVVQVVKPHT PLIRFPDRRD NPKPNVSEAL RSAGLPSHSS VISQHSKGSK SPDLLMYQGP PDTAEIIKTL PQKYRRKLVS QEEMEFIQRG GPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards