Small ribosomal subunit protein mS34 (MRPS34)

About Small ribosomal subunit protein mS34

Small ribosomal subunit protein mS34 (MRPS34) is a protein from Homo sapiens identified by UniProt accession P82930, 218 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Small ribosomal subunit protein mS34
UniProt accession	P82930
Gene	MRPS34
Organism	Homo sapiens
Length	218 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

Mitochondrial disorder due to a defect in mitochondrial protein synthesis · score 0.72
Leigh syndrome · score 0.44
neurodegenerative disease · score 0.37
Ataxia-telangiectasia · score 0.34
ataxia telangiectasia · score 0.34
genetic disorder · score 0.19
mitochondrial disease · score 0.12
autosomal recessive limb-girdle muscular dystrophy type 2L · score 0.04
myofibrillar myopathy 3 · score 0.04
Distal myotilinopathy · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P82930-F1	alphafold	PREDICTED	81.88	—

Amino-acid sequence (218 residues)

MARKKVRPRL IAELARRVRA LREQLNRPRD SQLYAVDYET LTRPFSGRRL PVRAWADVRR ESRLLQLLGR LPLFGLGRLV TRKSWLWQHD EPCYWRLTRV RPDYTAQNLD HGKAWGILTF KGKTESEARE IEHVMYHDWR LVPKHEEEAF TAFTPAPEDS LASVPYPPLL RAMIIAERQK NGDTSTEEPM LNVQRIRMEP WDYPAKQEDK GRAKGTPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards