SAP domain-containing ribonucleoprotein (SARNP)

About SAP domain-containing ribonucleoprotein

SAP domain-containing ribonucleoprotein (SARNP) is a protein from Homo sapiens identified by UniProt accession P82979, 210 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	SAP domain-containing ribonucleoprotein
UniProt accession	P82979
Gene	SARNP
Organism	Homo sapiens
Length	210 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
retinitis pigmentosa · score 0.07
Familial exudative vitreoretinopathy · score 0.06
snowflake vitreoretinal degeneration · score 0.05
X-linked retinoschisis · score 0.05
Coats disease · score 0.04
cataract 50 with or without glaucoma · score 0.04
Rare isolated myopia · score 0.04
Posterior polar cataract · score 0.04
Familial ocular anterior segment mesenchymal dysgenesis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P82979-F1	alphafold	PREDICTED	74.37	—

Amino-acid sequence (210 residues)

MATETVELHK LKLAELKQEC LARGLETKGI KQDLIHRLQA YLEEHAEEEA NEEDVLGDET EEEETKPIEL PVKEEEPPEK TVDVAAEKKV VKITSEIPQT ERMQKRAERF NVPVSLESKK AARAARFGIS SVPTKGLSSD NKPMVNLDKL KERAQRFGLN VSSISRKSED DEKLKKRKER FGIVTSSAGT GTTEDTEAKK RKRAERFGIA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards