ADAMTS-like protein 3 (ADAMTSL3)

About ADAMTS-like protein 3

ADAMTS-like protein 3 (ADAMTSL3) is a protein from Homo sapiens identified by UniProt accession P82987, 1691 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	ADAMTS-like protein 3
UniProt accession	P82987
Gene	ADAMTSL3
Organism	Homo sapiens
Length	1691 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

BMI-adjusted waist circumference · score 0.53
body height · score 0.51
BMI-adjusted hip circumference · score 0.49
FEV/FVC ratio · score 0.49
smoking behavior · score 0.48
physical activity measurement · score 0.48
body fat percentage · score 0.48
forced expiratory volume · score 0.47
asthma · score 0.47
body fat distribution · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P82987-F1	alphafold	PREDICTED	66.17	—

Amino-acid sequence (1691 residues)

MASWTSPWWV LIGMVFMHSP LPQTTAEKSP GAYFLPEFAL SPQGSFLEDT TGEQFLTYRY DDQTSRNTRS DEDKDGNWDA WGDWSDCSRT CGGGASYSLR RCLTGRNCEG QNIRYKTCSN HDCPPDAEDF RAQQCSAYND VQYQGHYYEW LPRYNDPAAP CALKCHAQGQ NLVVELAPKV LDGTRCNTDS LDMCISGICQ AVGCDRQLGS NAKEDNCGVC AGDGSTCRLV RGQSKSHVSP EKREENVIAV PLGSRSVRIT VKGPAHLFIE SKTLQGSKGE HSFNSPGVFL VENTTVEFQR GSERQTFKIP GPLMADFIFK TRYTAAKDSV VQFFFYQPIS HQWRQTDFFP CTVTCGGGYQ LNSAECVDIR LKRVVPDHYC HYYPENVKPK PKLKECSMDP CPSSDGFKEI MPYDHFQPLP RWEHNPWTAC SVSCGGGIQR RSFVCVEESM HGEILQVEEW KCMYAPKPKV MQTCNLFDCP KWIAMEWSQC TVTCGRGLRY RVVLCINHRG EHVGGCNPQL KLHIKEECVI PIPCYKPKEK SPVEAKLPWL KQAQELEETR IATEEPTFIP EPWSACSTTC GPGVQVREVK CRVLLTFTQT ETELPEEECE GPKLPTERPC LLEACDESPA SRELDIPLPE DSETTYDWEY AGFTPCTATC VGGHQEAIAV CLHIQTQQTV NDSLCDMVHR PPAMSQACNT EPCPPRWHVG SWGPCSATCG VGIQTRDVYC LHPGETPAPP EECRDEKPHA LQACNQFDCP PGWHIEEWQQ CSRTCGGGTQ NRRVTCRQLL TDGSFLNLSD ELCQGPKASS HKSCARTDCP PHLAVGDWSK CSVSCGVGIQ RRKQVCQRLA AKGRRIPLSE MMCRDLPGLP LVRSCQMPEC SKIKSEMKTK LGEQGPQILS VQRVYIQTRE EKRINLTIGS RAYLLPNTSV IIKCPVRRFQ KSLIQWEKDG RCLQNSKRLG ITKSGSLKIH GLAAPDIGVY RCIAGSAQET VVLKLIGTDN RLIARPALRE PMREYPGMDH SEANSLGVTW HKMRQMWNNK NDLYLDDDHI SNQPFLRALL GHCSNSAGST NSWELKNKQF EAAVKQGAYS MDTAQFDELI RNMSQLMETG EVSDDLASQL IYQLVAELAK AQPTHMQWRG IQEETPPAAQ LRGETGSVSQ SSHAKNSGKL TFKPKGPVLM RQSQPPSISF NKTINSRIGN TVYITKRTEV INILCDLITP SEATYTWTKD GTLLQPSVKI ILDGTGKIQI QNPTRKEQGI YECSVANHLG SDVESSSVLY AEAPVILSVE RNITKPEHNH LSVVVGGIVE AALGANVTIR CPVKGVPQPN ITWLKRGGSL SGNVSLLFNG SLLLQNVSLE NEGTYVCIAT NALGKAVATS VLHLLERRWP ESRIVFLQGH KKYILQATNT RTNSNDPTGE PPPQEPFWEP GNWSHCSATC GHLGARIQRP QCVMANGQEV SEALCDHLQK PLAGFEPCNI RDCPARWFTS VWSQCSVSCG EGYHSRQVTC KRTKANGTVQ VVSPRACAPK DRPLGRKPCF GHPCVQWEPG NRCPGRCMGR AVRMQQRHTA CQHNSSDSNC DDRKRPTLRR NCTSGACDVC WHTGPWKPCT AACGRGFQSR KVDCIHTRSC KPVAKRHCVQ KKKPISWRHC LGPSCDRDCT DTTHYCMFVK HLNLCSLDRY KQRCCQSCQE G

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards