About Serine protease HTRA4
Serine protease HTRA4 (HTRA4) is a protein
from Homo sapiens identified by UniProt accession
P83105, 476 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Serine protease HTRA4 |
|---|
| UniProt accession | P83105 |
|---|
| Gene | HTRA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 476 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- body height · score 0.22
- BMI-adjusted waist circumference · score 0.20
- monocyte count · score 0.17
- myeloid white cell count · score 0.14
- leukocyte count · score 0.13
- basophil count · score 0.12
- monocyte percentage of leukocytes · score 0.10
- drug-induced mental disorder · score 0.09
- protein measurement · score 0.09
- mean platelet volume · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P83105-F1 | alphafold | PREDICTED | 82.51 | — |
Amino-acid sequence (476 residues)
MIRPQLRTAG LGRCLLPGLL LLLVPVLWAG AEKLHTQPSC PAVCQPTRCP ALPTCALGTT PVFDLCRCCR VCPAAEREVC GGAQGQPCAP GLQCLQPLRP GFPSTCGCPT LGGAVCGSDR RTYPSMCALR AENRAARRLG KVPAVPVQWG NCGDTGTRSA GPLRRNYNFI AAVVEKVAPS VVHVQLWGRL LHGSRLVPVY SGSGFIVSED GLIITNAHVV RNQQWIEVVL QNGARYEAVV KDIDLKLDLA VIKIESNAEL PVLMLGRSSD LRAGEFVVAL GSPFSLQNTA TAGIVSTKQR GGKELGMKDS DMDYVQIDAT INYGNSGGPL VNLDGDVIGV NSLRVTDGIS FAIPSDRVRQ FLAEYHEHQM KGKAFSNKKY LGLQMLSLTV PLSEELKMHY PDFPDVSSGV YVCKVVEGTA AQSSGLRDHD VIVNINGKPI TTTTDVVKAL DSDSLSMAVL RGKDNLLLTV IPETIN
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