Serine protease HTRA3 (HTRA3)

About Serine protease HTRA3

Serine protease HTRA3 (HTRA3) is a protein from Homo sapiens identified by UniProt accession P83110, 453 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Serine protease HTRA3
UniProt accession	P83110
Gene	HTRA3
Organism	Homo sapiens
Length	453 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

pulse pressure measurement · score 0.34
carpal tunnel syndrome · score 0.33
systolic blood pressure · score 0.16
genetic disorder · score 0.12
aspartate aminotransferase measurement · score 0.10
low density lipoprotein cholesterol measurement · score 0.08
total cholesterol measurement · score 0.08
gonorrhea · score 0.05
esophageal squamous cell carcinoma · score 0.05
drug use measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P83110-F1	alphafold	PREDICTED	84.50	—

Amino-acid sequence (453 residues)

MQARALLLAA LAALALAREP PAAPCPARCD VSRCPSPRCP GGYVPDLCNC CLVCAASEGE PCGGPLDSPC GESLECVRGL CRCRWSHAVC GTDGHTYANV CALQAASRRA LQLSGTPVRQ LQKGACPLGL HQLSSPRYKF NFIADVVEKI APAVVHIELF LRHPLFGRNV PLSSGSGFIM SEAGLIITNA HVVSSNSAAP GRQQLKVQLQ NGDSYEATIK DIDKKSDIAT IKIHPKKKLP VLLLGHSADL RPGEFVVAIG SPFALQNTVT TGIVSTAQRE GRELGLRDSD MDYIQTDAII NYGNSGGPLV NLDGEVIGIN TLKVTAGISF AIPSDRITRF LTEFQDKQIK DWKKRFIGIR MRTITPSLVD ELKASNPDFP EVSSGIYVQE VAPNSPSQRG GIQDGDIIVK VNGRPLVDSS ELQEAVLTES PLLLEVRRGN DDLLFSIAPE VVM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards