About Serine beta-lactamase-like protein LACTB, mitochondrial
Serine beta-lactamase-like protein LACTB, mitochondrial (LACTB) is a protein
from Homo sapiens identified by UniProt accession
P83111, 547 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Serine beta-lactamase-like protein LACTB, mitochondrial |
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| UniProt accession | P83111 |
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| Gene | LACTB |
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| Organism | Homo sapiens |
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| Length | 547 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (65)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.35
- systolic blood pressure · score 0.34
- glomerular filtration rate · score 0.30
- serum metabolite measurement · score 0.30
- urinary metabolite measurement · score 0.27
- succinylcarnitine measurement · score 0.23
- alcohol drinking · score 0.23
- alcohol consumption measurement · score 0.22
- metabolite measurement · score 0.19
- diastolic blood pressure · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P83111-F1 | alphafold | PREDICTED | 78.91 | — |
Amino-acid sequence (547 residues)
MYRLMSAVTA RAAAPGGLAS SCGRRGVHQR AGLPPLGHGW VGGLGLGLGL ALGVKLAGGL RGAAPAQSPA APDPEASPLA EPPQEQSLAP WSPQTPAPPC SRCFARAIES SRDLLHRIKD EVGAPGIVVG VSVDGKEVWS EGLGYADVEN RVPCKPETVM RIASISKSLT MVALAKLWEA GKLDLDIPVQ HYVPEFPEKE YEGEKVSVTT RLLISHLSGI RHYEKDIKKV KEEKAYKALK MMKENVAFEQ EKEGKSNEKN DFTKFKTEQE NEAKCRNSKP GKKKNDFEQG ELYLREKFEN SIESLRLFKN DPLFFKPGSQ FLYSTFGYTL LAAIVERASG CKYLDYMQKI FHDLDMLTTV QEENEPVIYN RARFYVYNKK KRLVNTPYVD NSYKWAGGGF LSTVGDLLKF GNAMLYGYQV GLFKNSNENL LPGYLKPETM VMMWTPVPNT EMSWDKEGKY AMAWGVVERK QTYGSCRKQR HYASHTGGAV GASSVLLVLP EELDTETINN KVPPRGIIVS IICNMQSVGL NSTALKIALE FDKDRSD
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