About Conserved oligomeric Golgi complex subunit 7
Conserved oligomeric Golgi complex subunit 7 (COG7) is a protein
from Homo sapiens identified by UniProt accession
P83436, 770 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Conserved oligomeric Golgi complex subunit 7 |
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| UniProt accession | P83436 |
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| Gene | COG7 |
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| Organism | Homo sapiens |
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| Length | 770 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- COG7-congenital disorder of glycosylation · score 0.79
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.19
- congenital disorder of glycosylation · score 0.17
- breast adenocarcinoma · score 0.10
- macular corneal dystrophy · score 0.05
- X-linked endothelial corneal dystrophy · score 0.05
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
- granular corneal dystrophy type I · score 0.05
- autosomal dominant keratitis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P83436-F1 | alphafold | PREDICTED | 82.60 | — |
Amino-acid sequence (770 residues)
MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE VNHAVEETSH QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD TSQSMQVLVE IDQVKSRMQL AAESLQEADK WSTLSADIEE TFKTQDIAVI SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL KNRLEALASP QIVAAFTSQA VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC QSDLSLDRQL TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA VYDPYKPYQL KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG LASAAVDRCV RFTNGLGTCG LLSALKSLFA KYVSDFTSTL QSIRKKCKLD HIPPNSLFQE DWTAFQNSIR IIATCGELLR HCGDFEQQLA NRILSTAGKY LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP AEYASLMEIL YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS ALELALHAGK LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI PELSPHSAKQ LATDIDYLIN VMDALGLQPS RTLQHIVTLL KTRPEDYRQV SKGLPRRLAT TVATMRSVNY
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