Neuron-specific calcium-binding protein hippocalcin…

About Neuron-specific calcium-binding protein hippocalcin

Neuron-specific calcium-binding protein hippocalcin (HPCA) is a protein from Homo sapiens identified by UniProt accession P84074, 193 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Neuron-specific calcium-binding protein hippocalcin
UniProt accession	P84074
Gene	HPCA
Organism	Homo sapiens
Length	193 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

torsion dystonia 2 · score 0.73
neurodegenerative disease · score 0.34
body mass index · score 0.09
attention deficit hyperactivity disorder · score 0.05
amyotrophic lateral sclerosis · score 0.05
neurodegenerative syndrome due to cerebral folate transport deficiency · score 0.04
fat body mass · score 0.04
mosaic loss of chromosome Y measurement · score 0.04
schizophrenia 15 · score 0.04
central nervous system cancer · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P84074-F1	alphafold	PREDICTED	86.35	—

Amino-acid sequence (193 residues)

MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Neuron-specific calcium-binding protein hippocalcin (HPCA)