About ADP-ribosylation factor 1
ADP-ribosylation factor 1 (ARF1) is a protein
from Homo sapiens identified by UniProt accession
P84077, 181 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | ADP-ribosylation factor 1 |
|---|
| UniProt accession | P84077 |
|---|
| Gene | ARF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 181 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (119)
Diseases linked to this target (Open Targets).
- periventricular nodular heterotopia · score 0.75
- neurodegenerative disease · score 0.45
- HIV infection · score 0.37
- breast adenocarcinoma · score 0.25
- clear cell renal carcinoma · score 0.17
- adolescent idiopathic scoliosis · score 0.17
- glioblastoma · score 0.16
- cortical surface area measurement · score 0.15
- Charcot-Marie-Tooth disease · score 0.14
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P84077-F1 | alphafold | PREDICTED | 85.94 | — |
Amino-acid sequence (181 residues)
MGNIFANLFK GLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLSNQLRNQ K
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