About ADP-ribosylation factor 5
ADP-ribosylation factor 5 (ARF5) is a protein
from Homo sapiens identified by UniProt accession
P84085, 180 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | ADP-ribosylation factor 5 |
|---|
| UniProt accession | P84085 |
|---|
| Gene | ARF5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 180 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.22
- intelligence · score 0.21
- cognitive function measurement · score 0.21
- Abnormality of refraction · score 0.08
- self reported educational attainment · score 0.08
- hepatocellular carcinoma · score 0.08
- cancer · score 0.06
- neoplasm · score 0.04
- aspartate aminotransferase measurement · score 0.03
- breast cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P84085-F1 | alphafold | PREDICTED | 86.13 | — |
Amino-acid sequence (180 residues)
MGLTVSALFS RIFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV QESADELQKM LQEDELRDAV LLVFANKQDM PNAMPVSELT DKLGLQHLRS RTWYVQATCA TQGTGLYDGL DWLSHELSKR
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