Histone H3.3 (H3-3A)

About Histone H3.3

Histone H3.3 (H3-3A) is a protein from Homo sapiens identified by UniProt accession P84243, 136 residues long. MolForge cross-references it against 0 known binders and 287 disease associations.

Target properties

Protein name	Histone H3.3
UniProt accession	P84243
Gene	H3-3A
Organism	Homo sapiens
Length	136 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (287)

Diseases linked to this target (Open Targets).

Bryant-Li-Bhoj neurodevelopmental syndrome 1 · score 0.66
Bryant-Li-Bhoj neurodevelopmental syndrome 2 · score 0.62
oligodendroglioma · score 0.62
glioma susceptibility 1 · score 0.60
breast carcinoma · score 0.44
malignant glioma · score 0.44
astrocytoma · score 0.43
melanoma · score 0.42
pilocytic astrocytoma · score 0.40
genetic disorder · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P84243-F1	alphafold	PREDICTED	85.93	—

Amino-acid sequence (136 residues)

MARTKQTARK STGGKAPRKQ LATKAARKSA PSTGGVKKPH RYRPGTVALR EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards