Rho GTPase-activating protein 8 (ARHGAP8)

About Rho GTPase-activating protein 8

Rho GTPase-activating protein 8 (ARHGAP8) is a protein from Homo sapiens identified by UniProt accession P85298, 464 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Rho GTPase-activating protein 8
UniProt accession	P85298
Gene	ARHGAP8
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

binge eating · score 0.31
neurofibrillary tangles measurement · score 0.30
metabolite measurement · score 0.09
early-onset non-syndromic cataract · score 0.07
Cataract-microcornea syndrome · score 0.06
Total congenital cataract · score 0.06
isolated ectopia lentis · score 0.06
Cataract with Y-shaped suture opacities · score 0.05
Anterior polar cataract · score 0.05
Posterior polar cataract · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P85298-F1	alphafold	PREDICTED	75.78	—

Amino-acid sequence (464 residues)

MAGQDPALST SHPFYDVARH GILQVAGDDR FGRRVVTFSC CRMPPSHELD HQRLLEYLKY TLDQYVENDY TIVYFHYGLN SRNKPSLGWL QSAYKEFDRK DGDLTMWPRL VSNSKLKRSS HLSLPKYWDY RYKKNLKALY VVHPTSFIKV LWNILKPLIS HKFGKKVIYF NYLSELHEHL KYDQLVIPPE VLRYDEKLQS LHEGRTPPPT KTPPPRPPLP TQQFGVSLQY LKDKNQGELI PPVLRFTVTY LREKGLRTEG LFRRSASVQT VREIQRLYNQ GKPVNFDDYG DIHIPAVILK TFLRELPQPL LTFQAYEQIL GITCVESSLR VTGCRQILRS LPEHNYVVLR YLMGFLHAVS RESIFNKMNS SNLACVFGLN LIWPSQGVSS LSALVPLNMF TELLIEYYEK IFSTPEAPGE HGLAPWEQGS RAAPLQEAVP RTQATGLTKP TLPPSPLMAA RRRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards