Proline-rich protein 5 (PRR5)

About Proline-rich protein 5

Proline-rich protein 5 (PRR5) is a protein from Homo sapiens identified by UniProt accession P85299, 388 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Proline-rich protein 5
UniProt accession	P85299
Gene	PRR5
Organism	Homo sapiens
Length	388 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.29
endometrial cancer · score 0.28
neurodegenerative disease · score 0.27
lung adenocarcinoma · score 0.25
squamous cell lung carcinoma · score 0.23
urinary bladder cancer · score 0.19
neurofibrillary tangles measurement · score 0.15
metabolite measurement · score 0.07
cholesterol-ester transfer protein deficiency · score 0.04
hypertriglyceridemia 2 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P85299-F1	alphafold	PREDICTED	68.68	—

Amino-acid sequence (388 residues)

MRTLRRLKFM SSPSLSDLGK REPAAAADER GTQQRRACAN ATWNSIHNGV IAVFQRKGLP DQELFSLNEG VRQLLKTELG SFFTEYLQNQ LLTKGMVILR DKIRFYEGQK LLDSLAETWD FFFSDVLPML QAIFYPVQGK EPSVRQLALL HFRNAITLSV KLEDALARAH ARVPPAIVQM LLVLQGVHES RGVTEDYLRL ETLVQKVVSP YLGTYGLHSS EGPFTHSCIL EKRLLRRSRS GDVLAKNPVV RSKSYNTPLL NPVQEHEAEG AAAGGTSIRR HSVSEMTSCP EPQGFSDPPG QGPTGTFRSS PAPHSGPCPS RLYPTTQPPE QGLDPTRSSL PRSSPENLVD QILESVDSDS EGIFIDFGRG RGSGMSDLEG SGGRQSVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards