About Hydroxyacyl-thioester dehydratase type 2, mitochondrial
Hydroxyacyl-thioester dehydratase type 2, mitochondrial (HTD2) is a protein
from Homo sapiens identified by UniProt accession
P86397, 168 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Hydroxyacyl-thioester dehydratase type 2, mitochondrial |
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| UniProt accession | P86397 |
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| Gene | HTD2 |
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| Organism | Homo sapiens |
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| Length | 168 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- platelet count · score 0.23
- mean platelet volume · score 0.17
- uric acid measurement · score 0.16
- platelet crit · score 0.12
- total cholesterol measurement · score 0.10
- platelet component distribution width · score 0.09
- rheumatoid arthritis · score 0.08
- limited scleroderma · score 0.06
- 1,5 anhydroglucitol measurement · score 0.06
- Abnormality of refraction · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P86397-F1 | alphafold | PREDICTED | 85.33 | — |
Amino-acid sequence (168 residues)
MFPLISSHHL WWGGLRRTVC LNLPVLTLQH FQHMHIKVGD RAELRRAFTQ TDVATFSELT GDVNPLHLNE DFAKHTKFGN TIVHGVLING LISALLGTKM PGPGCVFLSQ EISFPAPLYI GEVVLASAEV KKLKRFIAII AVSCSVIESK KTVMEGWVKV MVPEASKS
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