Proline-rich protein 20E (PRR20E)

About Proline-rich protein 20E

Proline-rich protein 20E (PRR20E) is a protein from Homo sapiens identified by UniProt accession P86478, 221 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Proline-rich protein 20E
UniProt accession	P86478
Gene	PRR20E
Organism	Homo sapiens
Length	221 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

adolescent idiopathic scoliosis · score 0.19
self reported educational attainment · score 0.17
age at first sexual intercourse measurement · score 0.15
t-tau:beta-amyloid 1-42 ratio measurement · score 0.14
substance abuse · score 0.14
antisocial behaviour measurement · score 0.14
attention deficit hyperactivity disorder · score 0.14
lifestyle measurement · score 0.11
mosaic loss of chromosome Y measurement · score 0.03
facioscapulohumeral muscular dystrophy · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P86478-F1	alphafold	PREDICTED	48.22	—

Amino-acid sequence (221 residues)

MEEPRPSKRL RSMAPNQASG GPPPEPGCCV ADPEGSVEAD GPAQPAQPAK PIAYVKPFRR QPPARPESPP PAERGRRRGG SRRPGRGRGR RAGPRGDAGQ RQGAEGLMAP DVHIQLDHHG EPGHQGEPEI TETAAFSLSE TGPPPGTVQE GPGPDVAQPE LGFQEPPAAP GPQAVDWQPV LTLYPCIGFR ALGDSAVLQV IQTPQGTYVQ GVPVFLTDIA Y

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards