Vacuolar fusion protein CCZ1 homolog B (CCZ1B)

About Vacuolar fusion protein CCZ1 homolog B

Vacuolar fusion protein CCZ1 homolog B (CCZ1B) is a protein from Homo sapiens identified by UniProt accession P86790, 482 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Vacuolar fusion protein CCZ1 homolog B
UniProt accession	P86790
Gene	CCZ1B
Organism	Homo sapiens
Length	482 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
Myopia · score 0.23
age at onset · score 0.23
appendicular lean mass · score 0.23
reticulocyte measurement · score 0.22
mitochondrial heteroplasmy measurement · score 0.19
refractive error · score 0.19
reticulocyte count · score 0.11
sex hormone-binding globulin measurement · score 0.07
leukocyte count · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P86790-F1	alphafold	PREDICTED	88.10	—

Amino-acid sequence (482 residues)

MAAAAAGAGS GPWAAQEKQF PPALLSFFIY NPRFGPREGQ EENKILFYHP NEVEKNEKIR NVGLCEAIVQ FTRTFSPSKP AKSLHTQKNR QFFNEPEENF WMVMVVRNPI IEKQSKDGKP VIEYQEEELL DKVYSSVLRQ CYSMYKLFNG TFLKAMEDGG VKLLKERLEK FFHRYLQTLH LQSCDLLDIF GGISFFPLDK MTYLKIQSFI NRMEESLNIV KYTAFLYNDQ LIWSGLEQDD MRILYKYLTT SLFPRHIEPE LAGRDSPIRA EMPGNLQHYG RFLTGPLNLN DPDAKCRFPK IFVNTDDTYE ELHLIVYKAM SAAVCFMIDA SVHPTLDFCR RLDSIVGPQL TVLASDICEQ FNINKRMSGS EKEPQFKFIY FNHMNLAEKS TVHMRKTPSV SLTSVHPDLM KILGDINSDF TRVDEDEEII VKAMSDYWVV GKKSDRRELY VILNQKNANL IEVNEEVKKL CATQFNNIFF LD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards