About SHC-transforming protein 2
SHC-transforming protein 2 (SHC2) is a protein
from Homo sapiens identified by UniProt accession
P98077, 582 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | SHC-transforming protein 2 |
|---|
| UniProt accession | P98077 |
|---|
| Gene | SHC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 582 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (74)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.29
- sensorineural hearing loss · score 0.24
- disorder of ear · score 0.13
- protein measurement · score 0.12
- reticulocyte measurement · score 0.06
- multiple system atrophy · score 0.05
- reticulocyte count · score 0.05
- lymphocyte percentage of leukocytes · score 0.03
- chronic kidney disease · score 0.03
- ulcerative colitis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P98077-F1 | alphafold | PREDICTED | 61.81 | — |
Amino-acid sequence (582 residues)
MTQGPGGRAP PAPPAPPEPE APTTFCALLP RMPQWKFAAP GGFLGRGPAA ARAAGASGGA DPQPEPAGPG GVPALAAAVL GACEPRCAAP CPLPALSRCR GAGSRGSRGG RGAAGSGDAA AAAEWIRKGS FIHKPAHGWL HPDARVLGPG VSYVVRYMGC IEVLRSMRSL DFNTRTQVTR EAINRLHEAV PGVRGSWKKK APNKALASVL GKSNLRFAGM SISIHISTDG LSLSVPATRQ VIANHHMPSI SFASGGDTDM TDYVAYVAKD PINQRACHIL ECCEGLAQSI ISTVGQAFEL RFKQYLHSPP KVALPPERLA GPEESAWGDE EDSLEHNYYN SIPGKEPPLG GLVDSRLALT QPCALTALDQ GPSPSLRDAC SLPWDVGSTG TAPPGDGYVQ ADARGPPDHE EHLYVNTQGL DAPEPEDSPK KDLFDMRPFE DALKLHECSV AAGVTAAPLP LEDQWPSPPT RRAPVAPTEE QLRQEPWYHG RMSRRAAERM LRADGDFLVR DSVTNPGQYV LTGMHAGQPK HLLLVDPEGV VRTKDVLFES ISHLIDHHLQ NGQPIVAAES ELHLRGVVSR EP
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