About Integral membrane protein DGCR2/IDD
Integral membrane protein DGCR2/IDD (DGCR2) is a protein
from Homo sapiens identified by UniProt accession
P98153, 550 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Integral membrane protein DGCR2/IDD |
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| UniProt accession | P98153 |
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| Gene | DGCR2 |
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| Organism | Homo sapiens |
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| Length | 550 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.33
- glomerular filtration rate · score 0.16
- platelet crit · score 0.06
- metabolite measurement · score 0.05
- serum metabolite measurement · score 0.05
- ghosal hematodiaphyseal dysplasia · score 0.04
- blood metabolite measurement · score 0.04
- cancer · score 0.04
- osteopathia striata-pigmentary dermopathy-white forelock syndrome · score 0.04
- myeloid white cell count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P98153-F1 | alphafold | PREDICTED | 63.08 | — |
Amino-acid sequence (550 residues)
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ CDGWATCEDE SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV NVAQPVRFSS FLGKCPTGWH HYEGTASCYR VYLSGENYWD AAQTCQRLNG SLATFSTDQE LRFVLAQEWD QPERSFGWKD QRKLWVGYQY VITGRNRSLE GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH FPTLRHHDLH SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL VVSCISSFLI LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD YGPDGFGTGL TPLHLSDDGE GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP YEASIHPDSV FYDPADDDAF EPVEVSLPAP GDGGSEGALL RRLEQPLPTA GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR HSRSSLNTVV
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