About Ephrin-B1
Ephrin-B1 (EFNB1) is a protein
from Homo sapiens identified by UniProt accession
P98172, 346 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | Ephrin-B1 |
|---|
| UniProt accession | P98172 |
|---|
| Gene | EFNB1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 346 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (217)
Diseases linked to this target (Open Targets).
- craniofrontonasal syndrome · score 0.81
- Craniofrontonasal dysplasia · score 0.80
- genetic disorder · score 0.41
- lung adenocarcinoma · score 0.14
- head and neck squamous cell carcinoma · score 0.12
- schizencephaly · score 0.11
- mirror movements 1 · score 0.11
- Syndactyly type 2 · score 0.08
- hepatocellular carcinoma · score 0.08
- Rheumatoid arthritis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P98172-F1 | alphafold | PREDICTED | 70.66 | — |
Amino-acid sequence (346 residues)
MARPGQRWLG KWLVAMVVWA LCRLATPLAK NLEPVSWSSL NPKFLSGKGL VIYPKIGDKL DIICPRAEAG RPYEYYKLYL VRPEQAAACS TVLDPNVLVT CNRPEQEIRF TIKFQEFSPN YMGLEFKKHH DYYITSTSNG SLEGLENREG GVCRTRTMKI IMKVGQDPNA VTPEQLTTSR PSKEADNTVK MATQAPGSRG SLGDSDGKHE TVNQEEKSGP GASGGSSGDP DGFFNSKVAL FAAVGAGCVI FLLIIIFLTV LLLKLRKRHR KHTQQRAAAL SLSTLASPKG GSGTAGTEPS DIIIPLRTTE NNYCPHYEKV SGDYGHPVYI VQEMPPQSPA NIYYKV
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