Forkhead box protein O4 (FOXO4)

About Forkhead box protein O4

Forkhead box protein O4 (FOXO4) is a protein from Homo sapiens identified by UniProt accession P98177, 505 residues long. MolForge cross-references it against 0 known binders and 302 disease associations.

Target properties

Protein name	Forkhead box protein O4
UniProt accession	P98177
Gene	FOXO4
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (302)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
Endometrial Endometrioid Adenocarcinoma · score 0.37
lung adenocarcinoma · score 0.32
head and neck squamous cell carcinoma · score 0.30
non-small cell lung carcinoma · score 0.30
breast adenocarcinoma · score 0.28
acute myeloid leukemia · score 0.28
hepatocellular carcinoma · score 0.28
melanoma · score 0.28
oral squamous cell carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P98177-F1	alphafold	PREDICTED	54.29	—

Amino-acid sequence (505 residues)

MDPGNENSAT EAAAIIDLDP DFEPQSRPRS CTWPLPRPEI ANQPSEPPEV EPDLGEKVHT EGRSEPILLP SRLPEPAGGP QPGILGAVTG PRKGGSRRNA WGNQSYAELI SQAIESAPEK RLTLAQIYEW MVRTVPYFKD KGDSNSSAGW KNSIRHNLSL HSKFIKVHNE ATGKSSWWML NPEGGKSGKA PRRRAASMDS SSKLLRGRSK APKKKPSVLP APPEGATPTS PVGHFAKWSG SPCSRNREEA DMWTTFRPRS SSNASSVSTR LSPLRPESEV LAEEIPASVS SYAGGVPPTL NEGLELLDGL NLTSSHSLLS RSGLSGFSLQ HPGVTGPLHT YSSSLFSPAE GPLSAGEGCF SSSQALEALL TSDTPPPPAD VLMTQVDPIL SQAPTLLLLG GLPSSSKLAT GVGLCPKPLE APGPSSLVPT LSMIAPPPVM ASAPIPKALG TPVLTPPTEA ASQDRMPQDL DLDMYMENLE CDMDNIISDL MDEGEGLDFN FEPDP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards