About Cytochrome P450 4F8
Cytochrome P450 4F8 (CYP4F8) is a protein
from Homo sapiens identified by UniProt accession
P98187, 520 residues long.
MolForge cross-references it against 0 known binders and
136 disease associations.
Target properties
| Protein name | Cytochrome P450 4F8 |
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| UniProt accession | P98187 |
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| Gene | CYP4F8 |
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| Organism | Homo sapiens |
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| Length | 520 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (136)
Diseases linked to this target (Open Targets).
- age-related macular degeneration · score 0.09
- X-linked retinal dysplasia · score 0.09
- retinitis pigmentosa · score 0.08
- severe early-childhood-onset retinal dystrophy · score 0.07
- Familial exudative vitreoretinopathy · score 0.07
- age related macular degeneration 11 · score 0.07
- age related macular degeneration 4 · score 0.07
- age related macular degeneration 7 · score 0.07
- snowflake vitreoretinal degeneration · score 0.06
- X-linked retinoschisis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P98187-F1 | alphafold | PREDICTED | 91.28 | — |
Amino-acid sequence (520 residues)
MSLLSLSWLG LRPVAASPWL LLLVVGASWL LARILAWTYA FYHNGRRLRC FPQPRKQNWF LGHLGLVTPT EEGLRVLTQL VATYPQGFVR WLGPITPIIN LCHPDIVRSV INTSDAITDK DIVFYKTLKP WLGDGLLLSV GDKWRHHRRL LTPAFHFNIL KPYIKIFSKS ANIMHAKWQR LAMEGSTCLD VFEHISLMTL DSLQKCIFSF DSNCQEKPSE YITAIMELSA LVVKRNNQFF RYKDFLYFLT PCGRRFHRAC RLVHDFTDAV IQERRRTLTS QGVDDFLQAK AKSKTLDFID VLLLSEDKNG KELSDEDIRA EADTFMFGGH DTTASGLSWV LYNLARHPEY QERCRQEVQE LLKDREPKEI EWDDLAQLPF LTMCLKESLR LHPPIPTFAR GCTQDVVLPD SRVIPKGNVC NINIFAIHHN PSVWPDPEVY DPFRFDPENA QKRSPMAFIP FSAGPRNCIG QKFAMAEMKV VLALTLLRFR ILPDHREPRR TPEIVLRAED GLWLRVEPLG
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