About Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B) is a protein
from Homo sapiens identified by UniProt accession
Q00005, 443 residues long.
MolForge cross-references it against 0 known binders and
175 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform |
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| UniProt accession | Q00005 |
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| Gene | PPP2R2B |
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| Organism | Homo sapiens |
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| Length | 443 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (175)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 12 · score 0.51
- neurodegenerative disease · score 0.50
- schizophrenia · score 0.41
- mathematical ability · score 0.37
- neuroticism measurement · score 0.29
- unipolar depression · score 0.29
- autism spectrum disorder · score 0.29
- bipolar disorder · score 0.29
- obsessive-compulsive disorder · score 0.29
- Tourette syndrome · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q00005-F1 | alphafold | PREDICTED | 90.49 | — |
Amino-acid sequence (443 residues)
MEEDIDTRKI NNSFLRDHSY ATEADIISTV EFNHTGELLA TGDKGGRVVI FQREQESKNQ VHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAYFLLST NDKTVKLWKV SERDKRPEGY NLKDEEGRLR DPATITTLRV PVLRPMDLMV EATPRRVFAN AHTYHINSIS VNSDYETYMS ADDLRINLWN FEITNQSFNI VDIKPANMEE LTEVITAAEF HPHHCNTFVY SSSKGTIRLC DMRASALCDR HTKFFEEPED PSNRSFFSEI ISSISDVKFS HSGRYIMTRD YLTVKVWDLN MENRPIETYQ VHDYLRSKLC SLYENDCIFD KFECVWNGSD SVIMTGSYNN FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCVGGKRR KDEISVDSLD FSKKILHTAW HPSENIIAVA ATNNLYIFQD KVN
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