55 kDa erythrocyte membrane protein (MPP1)

About 55 kDa erythrocyte membrane protein

55 kDa erythrocyte membrane protein (MPP1) is a protein from Homo sapiens identified by UniProt accession Q00013, 466 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	55 kDa erythrocyte membrane protein
UniProt accession	Q00013
Gene	MPP1
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
neutrophil immunodeficiency syndrome · score 0.06
Recurrent infection due to specific granule deficiency · score 0.04
immunodeficiency 81 · score 0.03
Pelger-Huet-like anomaly and episodic fever with abdominal pain · score 0.03
Leishmaniasis · score 0.01
Ataxia-telangiectasia · score 0.01
Alzheimer disease · score 0.01
osteosarcoma · score 0.01
ulcerative colitis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00013-F1	alphafold	PREDICTED	78.13	—

Amino-acid sequence (466 residues)

MTLKASEGES GGSMHTALSD LYLEHLLQKR SRPEAVSHPL NTVTEDMYTN GSPAPGSPAQ VKGQEVRKVR LIQFEKVTEE PMGITLKLNE KQSCTVARIL HGGMIHRQGS LHVGDEILEI NGTNVTNHSV DQLQKAMKET KGMISLKVIP NQQSRLPALQ MFMRAQFDYD PKKDNLIPCK EAGLKFATGD IIQIINKDDS NWWQGRVEGS SKESAGLIPS PELQEWRVAS MAQSAPSEAP SCSPFGKKKK YKDKYLAKHS SIFDQLDVVS YEEVVRLPAF KRKTLVLIGA SGVGRSHIKN ALLSQNPEKF VYPVPYTTRP PRKSEEDGKE YHFISTEEMT RNISANEFLE FGSYQGNMFG TKFETVHQIH KQNKIAILDI EPQTLKIVRT AELSPFIVFI APTDQGTQTE ALQQLQKDSE AIRSQYAHYF DLSLVNNGVD ETLKKLQEAF DQACSSPQWV PVSWVY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards