Homeobox protein Hox-A4 (HOXA4)

About Homeobox protein Hox-A4

Homeobox protein Hox-A4 (HOXA4) is a protein from Homo sapiens identified by UniProt accession Q00056, 320 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	Homeobox protein Hox-A4
UniProt accession	Q00056
Gene	HOXA4
Organism	Homo sapiens
Length	320 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.22
systolic blood pressure · score 0.18
diastolic blood pressure · score 0.18
hypertension · score 0.16
sex hormone-binding globulin measurement · score 0.16
head and neck squamous cell carcinoma · score 0.15
pulse pressure measurement · score 0.15
hypospadias · score 0.14
mean arterial pressure · score 0.13
lymphocyte percentage of leukocytes · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00056-F1	alphafold	PREDICTED	61.82	—

Amino-acid sequence (320 residues)

MTMSSFLINS NYIEPKFPPF EEYAQHSGSG GADGGPGGGP GYQQPPAPPT QHLPLQQPQL PHAGGGREPT ASYYAPRTAR EPAYPAAALY PAHGAADTAY PYGYRGGASP GRPPQPEQPP AQAKGPAHGL HASHVLQPQL PPPLQPRAVP PAAPRRCEAA PATPGVPAGG SAPACPLLLA DKSPLGLKGK EPVVYPWMKK IHVSAVNPSY NGGEPKRSRT AYTRQQVLEL EKEFHFNRYL TRRRRIEIAH TLCLSERQVK IWFQNRRMKW KKDHKLPNTK MRSSNSASAS AGPPGKAQTQ SPHLHPHPHP STSTPVPSSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards