Transcription factor A, mitochondrial (TFAM)

About Transcription factor A, mitochondrial

Transcription factor A, mitochondrial (TFAM) is a protein from Homo sapiens identified by UniProt accession Q00059, 246 residues long. MolForge cross-references it against 0 known binders and 312 disease associations.

Target properties

Protein name	Transcription factor A, mitochondrial
UniProt accession	Q00059
Gene	TFAM
Organism	Homo sapiens
Length	246 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (312)

Diseases linked to this target (Open Targets).

mitochondrial DNA depletion syndrome 15 (hepatocerebral type) · score 0.67
neurodegenerative disease · score 0.55
mitochondrial DNA measurement · score 0.38
mitochondrial heteroplasmy measurement · score 0.30
Sensorineural hearing impairment · score 0.11
sensorineural hearing loss · score 0.11
Premature ovarian insufficiency · score 0.11
chronic obstructive pulmonary disease · score 0.10
hepatocellular carcinoma · score 0.09
non-small cell lung carcinoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00059-F1	alphafold	PREDICTED	85.39	—

Amino-acid sequence (246 residues)

MAFLRSMWGV LSALGRSGAE LCTGCGSRLR SPFSFVYLPR WFSSVLASCP KKPVSSYLRF SKEQLPIFKA QNPDAKTTEL IRRIAQRWRE LPDSKKKIYQ DAYRAEWQVY KEEISRFKEQ LTPSQIMSLE KEIMDKHLKR KAMTKKKELT LLGKPKRPRS AYNVYVAERF QEAKGDSPQE KLKTVKENWK NLSDSEKELY IQHAKEDETR YHNEMKSWEE QMIEVGRKDL LRRTIKKQRK YGAEEC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards