About S-adenosylmethionine synthase isoform type-1
S-adenosylmethionine synthase isoform type-1 (MAT1A) is a protein
from Homo sapiens identified by UniProt accession
Q00266, 395 residues long.
MolForge cross-references it against 0 known binders and
173 disease associations.
Target properties
| Protein name | S-adenosylmethionine synthase isoform type-1 |
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| UniProt accession | Q00266 |
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| Gene | MAT1A |
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| Organism | Homo sapiens |
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| Length | 395 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (173)
Diseases linked to this target (Open Targets).
- methionine adenosyltransferase deficiency · score 0.80
- Brain demyelination due to methionine adenosyltransferase deficiency · score 0.73
- hepatic methionine adenosyltransferase deficiency · score 0.57
- neurodegenerative disease · score 0.38
- Psychomotor retardation due to S-adenosylhomocysteine hydrolase deficiency · score 0.37
- vitamin D measurement · score 0.36
- systolic blood pressure · score 0.30
- cystatin C measurement · score 0.22
- hematocrit · score 0.19
- genetic disorder · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q00266-F1 | alphafold | PREDICTED | 96.56 | — |
Amino-acid sequence (395 residues)
MNGPVDGLCD HSLSEGVFMF TSESVGEGHP DKICDQISDA VLDAHLKQDP NAKVACETVC KTGMVLLCGE ITSMAMVDYQ RVVRDTIKHI GYDDSAKGFD FKTCNVLVAL EQQSPDIAQC VHLDRNEEDV GAGDQGLMFG YATDETEECM PLTIILAHKL NARMADLRRS GLLPWLRPDS KTQVTVQYMQ DNGAVIPVRI HTIVISVQHN EDITLEEMRR ALKEQVIRAV VPAKYLDEDT VYHLQPSGRF VIGGPQGDAG VTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH KNFDLRPGVI VRDLDLKKPI YQKTACYGHF GRSEFPWEVP RKLVF
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