Solute carrier family 25 member 3 (SLC25A3)

About Solute carrier family 25 member 3

Solute carrier family 25 member 3 (SLC25A3) is a protein from Homo sapiens identified by UniProt accession Q00325, 362 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Solute carrier family 25 member 3
UniProt accession	Q00325
Gene	SLC25A3
Organism	Homo sapiens
Length	362 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

Cardiomyopathy - hypotonia - lactic acidosis · score 0.71
cardiomyopathy-hypotonia-lactic acidosis syndrome · score 0.64
neurodegenerative disease · score 0.54
blood protein measurement · score 0.25
mitochondrial disease · score 0.18
smoking status measurement · score 0.14
metabolite measurement · score 0.12
pulse pressure measurement · score 0.10
neuropathic pain · score 0.07
lung adenocarcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00325-F1	alphafold	PREDICTED	79.83	—

Amino-acid sequence (362 residues)

MFSSVAHLAR ANPFNTPHLQ LVHDGLGDLR SSSPGPTGQP RRPRNLAAAA VEEQYSCDYG SGRFFILCGL GGIISCGTTH TALVPLDLVK CRMQVDPQKY KGIFNGFSVT LKEDGVRGLA KGWAPTFLGY SMQGLCKFGF YEVFKVLYSN MLGEENTYLW RTSLYLAASA SAEFFADIAL APMEAAKVRI QTQPGYANTL RDAAPKMYKE EGLKAFYKGV APLWMRQIPY TMMKFACFER TVEALYKFVV PKPRSECSKP EQLVVTFVAG YIAGVFCAIV SHPADSVVSV LNKEKGSSAS LVLKRLGFKG VWKGLFARII MIGTLTALQW FIYDSVKVYF RLPRPPPPEM PESLKKKLGL TQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards