Transcription initiation factor IIB (GTF2B)

About Transcription initiation factor IIB

Transcription initiation factor IIB (GTF2B) is a protein from Homo sapiens identified by UniProt accession Q00403, 316 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	Transcription initiation factor IIB
UniProt accession	Q00403
Gene	GTF2B
Organism	Homo sapiens
Length	316 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

HIV infection · score 0.58
systolic blood pressure · score 0.26
hypertension · score 0.24
serum gamma-glutamyl transferase measurement · score 0.23
body height · score 0.22
pulse pressure measurement · score 0.18
blood pressure · score 0.18
hemoglobin measurement · score 0.18
hematocrit · score 0.17
monocyte count · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00403-F1	alphafold	PREDICTED	87.24	—

Amino-acid sequence (316 residues)

MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS EWRTFSNDKA TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK YQNRRTMSSS DRAMMNAFKE ITTMADRINL PRNIVDRTNN LFKQVYEQKS LKGRANDAIA SACLYIACRQ EGVPRTFKEI CAVSRISKKE IGRCFKLILK ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV ELDLVPGRSP ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF PTDFKFDTPV DKLPQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards