Cyclin-dependent kinase-like 1 (CDKL1)

About Cyclin-dependent kinase-like 1

Cyclin-dependent kinase-like 1 (CDKL1) is a protein from Homo sapiens identified by UniProt accession Q00532, 357 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Cyclin-dependent kinase-like 1
UniProt accession	Q00532
Gene	CDKL1
Organism	Homo sapiens
Length	357 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (66)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.41
mean corpuscular hemoglobin concentration · score 0.40
systolic blood pressure · score 0.32
aspartate aminotransferase measurement · score 0.32
mean corpuscular hemoglobin · score 0.30
Palmar Fibromatosis · score 0.25
Fasciitis · score 0.24
hemoglobin measurement · score 0.19
red blood cell density measurement · score 0.17
vitamin D measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q00532-F1	alphafold	PREDICTED	82.18	—

Amino-acid sequence (357 residues)

MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKKFLESED DPVIKKIALR EIRMLKQLKH PNLVNLLEVF RRKRRLHLVF EYCDHTVLHE LDRYQRGVPE HLVKSITWQT LQAVNFCHKH NCIHRDVKPE NILITKHSVI KLCDFGFARL LTGPSDYYTD YVATRWYRSP ELLVGDTQYG PPVDVWAIGC VFAELLSGVP LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS TNQYFSGVKI PDPEDMEPLE LKFPNISYPA LGLLKGCLHM DPTQRLTCEQ LLHHPYFENI REIEDLAKEH NKPTRKTLRK SRKHHCFTET SKLQYLPQLT GSSILPALDN KKYYCDTKKL NYRFPNI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards